The future of diabetes treatment may soon be revolutionized by genetic approaches. On the 21st, Biochip Shanghai National Engineering Research Center and Hangzhou Yiyuan Biotechnology Co., Ltd. jointly announced a groundbreaking development: the use of a mutated glucokinase gene to treat type 2 diabetes. This marks a significant step forward in the field of gene therapy for metabolic disorders.
Glucokinase plays a critical role in the body's glucose-sensing and regulatory system. After over a decade of research, scientists discovered that this enzyme can enhance glucose-stimulated insulin secretion, allowing the body to naturally regulate blood sugar levels. This mechanism offers a potential cure for diabetes at its root. However, challenges remain—such as the low activity of the native glucokinase protein and the risk of severe hypoglycemia in experimental animals, which raises safety concerns.
To address these issues, researchers engineered a mutated version of the glucokinase gene. Preclinical trials have shown promising results, with the mutant gene demonstrating both effectiveness and improved safety in treating type 2 diabetes. These findings suggest a bright future for glycemic control and long-term diabetes management.
Globally, approximately 250 million people live with type 2 diabetes, and the number is rising by about 10% annually, with cases increasingly appearing in younger populations. As the disease becomes more prevalent, there's a growing need for innovative therapies that target the body’s natural mechanisms to lower blood sugar. This research, conducted without prior precedent in China, represents a major milestone in the development of gene-based treatments for diabetes.
Auto Parts
This classification mainly includes the aluminum alloy die casting parts using in Auto area,the raw material is aluminum alloy.
In the die casting process,higher specific pressure is required, so that higher filling speed can be obtained.which is beneficial for alloy to overcome mold filling resistance.and effectively fill each part of the cavity.The Casting General Tolerance is Grade GB-CT4.
Process Technology: High pressure die casting, Cold Chamber
Product Dimensions: Customized
Casting General Tolerance: Grade GB-CT4
Flow Processes: Die casting, Degating to remove the residual of the gate, Polishing and Deburring to remove the burrs, Polishing to remove the parting line, flash,CNC Turning, Cleaning, Packaging, Storaging, Shipping
Control Measure: Incoming Material Test, First Article inspection, Routing inspection, Final item inspection, and Outgoing quality control
Inspection Equipment: CMM, Caliper, Plug Gage, Screw Gauge
Application: Machinery Parts
Certificate: IATF16949:2016,ISO14001:2015,ISO45001:2018
Lead Time: 30-35 days
Trade Term: FOB Ningbo
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