Recently, supported by the National Natural Science Foundation, Professor Xi Xinyan and Wang Xin from Xijing Hospital, Fourth Military Medical University, conducted a study that demonstrated genistein (GEN) can effectively suppress the growth of ovarian cancer xenografts in nude mice. This discovery offers promising new directions for enhancing the clinical treatment of ovarian cancer.
Ovarian cancer is one of the most common and deadly gynecological malignancies. Cisplatin (DDP) has long been a standard chemotherapy drug for treating this disease, but its significant toxic side effects often make it difficult for patients to tolerate, limiting its broader use. In contrast, genistein, a naturally occurring phytoestrogen found in various plants, has shown potent anti-cancer properties in both in vitro and in vivo studies against breast, prostate, and colon cancers.
In this study, researchers established 20 human ovarian cancer xenograft models in nude mice and randomly assigned them into four groups. The results revealed that GEN significantly inhibited tumor growth and exhibited a synergistic effect when combined with DDP. Mechanistically, GEN was found to suppress tumor cell proliferation and inhibit the formation of new blood vessels within the tumor, thereby disrupting the tumor's blood supply and slowing its progression.
This research highlights the potential of genistein as an effective and safer alternative or complementary therapy for ovarian cancer treatment, offering hope for more targeted and less toxic approaches in the future.
Portable Powder Fire Extinguisher
Portable Powder Fire Extinguisher,Abc Powder Fire Extinguisher,Dry Powder Extinguisher,Powder Fire Extinguisher
Nanjing Txfire International Trade Co., Ltd , https://www.txfireequipment.com