Flavonoids can inhibit the growth of ovarian cancer xenografts
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Recently, supported by the National Natural Science Foundation, Professor Xi Xinyan and Wang Xin from Xijing Hospital, Fourth Military Medical University, conducted a study confirming that genistein (GEN) significantly inhibits the growth of ovarian cancer xenografts in nude mice. This promising research opens new possibilities for enhancing the effectiveness of ovarian cancer treatment in clinical settings.
Ovarian cancer is one of the most common and deadly gynecological malignancies. Cisplatin (DDP), a widely used chemotherapeutic agent, is effective against this disease, but its severe side effects often limit its use. Many patients experience toxicity that makes it difficult to tolerate, which hinders long-term treatment strategies.
Genistein, a naturally occurring phytoestrogen found in various plants, has shown strong anti-cancer properties in both in vitro and in vivo studies. It has been reported to inhibit the growth of breast, prostate, and colon cancer cells, suggesting its potential as an alternative or complementary therapy.
In this study, researchers established 20 human ovarian cancer xenograft models in nude mice and divided them into four groups. The results showed that GEN significantly suppressed tumor growth and exhibited a synergistic effect when combined with DDP. Further analysis revealed that GEN works by inhibiting tumor cell proliferation and reducing neovascularization within the tumor, thereby cutting off the blood supply and limiting tumor progression.
These findings highlight the potential of genistein as a valuable adjunct to conventional chemotherapy, offering a safer and more effective approach for ovarian cancer treatment. More research is needed to explore its mechanisms and optimize its application in clinical practice.