Model NO.: Follistatin 315
Water Content(Karl Fischer): 5.0%
Acetate Content(by HPLC): 15.0%
Trademark: DMK
Transport Package: Aluminum Foil Bag/Carton
Specification: API
Origin: China
HS Code: 29061310
Model NO.: Follistatin 315
Water Content(Karl Fischer): 5.0%
Acetate Content(by HPLC): 15.0%
Trademark: DMK
Transport Package: Aluminum Foil Bag/Carton
Specification: API
Origin: China
HS Code: 29061310
USP Standard Follistatin 315 Powder From GMP Factory Professional Supply for Bodybuilder
What is FollistatinÂ
Follistatin is fascinating protein that can increase muscle mass beyond natural potential by suppressing myostatin. Scientists first identified follistatin while examining porcine (re: pig) follicular fluid in the ovaries. Follistatin is naturally found in the skeletal muscle of almost all mammals with advanced or developed characteristics, such as humans, rodents, and cows. Follistatin is high in the non-essential amino acid cystine but unlike most proteins discussed in the fitness world, follistatin has carbohydrates attached to it.Â
Follistatin, specifically Follistatin 344 (FS344), quickly gained popularity in the bodybuilding community as a potential supplement to rapidly increase lean tissue mass. Another protein, follistatin-related gene (FLRG) acts on similar pathways as FS344 regarding its muscle building properties. Increased lean tissue mass could give a bodybuilder an advantage in a competitive setting and be the differentiating factor between first and second place.
Follistatin (FS) was initially identified as a follicle-stimulating hormone inhibiting substance found in ovarian follicular fluid. FS is a high-affinity activin-binding protein that can act as an activin antagonist. Two alternatively spliced follistatin mRNAs exist, encoding mature FS with 288 amino acid (aa) residues (FS-288) and 315 aa residues (FS-315). Natural FS purified from porcine ovaries is primarily a carboxy-terminal truncated form of FS-315 composed of 300 aa residues.
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. Follistatin binds directly to activin and functions as an activin antagonist. specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh).
***************************************************************************
Specification: 1mg/vial
Purity: 98%min
Appearance: White powder
Specific Optical Rotation (c=0.5,10% HAc) :-50.0~-60.0°
Water Content(Karl Fischer): ≤5.0%
Acetate Content(by HPLC): ≤15.0%
Amino Acid Composition: ±10% of theoretical
Purity (by HPLC) :≥98.0%
Single Impurity(by HPLC): ≤1.0%
Peptide Content(by %N): ≥80%
Assay(By Anhydrous, Acetic Acid-free ): 95.0~105.0%
Bacterial Endotoxins : ≤5EU/mg
Storage/Stability: Stored at -20 °C if preferred. Storage in frost-free freezers is not recommended.
***************************************************************************
Follistatin 315 (FST-315):
Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle?stimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an N?terminal atypical TGF binding domain, three Follistatin domains that contain EGF?like and kazal?like motifs, and a highly acidic C?terminal tail. Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-Beta ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin 315 is a 34.7 kDa protein containing amino acids 30-344 of the FST-344 protein.
***************************************************************************
Application of Follistatin
Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle stimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an Nterminal atypical TGF binding domain, three Follistatin domains that contain EGFlike and kazallike motifs, and a highly acidic Cterminal tail. Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-Beta ligands including BMP-2, -4, -6, -7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 37.8 kDa protein containing 344 amino acids .
Follistatin and Muscle Growth:
Follistatin works by binding to and inhibiting transforming grow factor- (TGF-) peptides such as myostatin which is responsible for regulating and limiting muscle growth. Â It's also worth pointing out that myostatin may have a regulatory role in skeletal muscle fibrosis; too much myostatin can impair tissue function and cause chronic disease in vital organs, tissues, and bone marrow. In additional to suppressing the degenerative properties of myostatin, follistatin also suppresses the pituitary gland synthesis and secretion of follicle-stimulating hormone (FSH). [1] High FSH levels in men may indicate that testicles are not functioning correctly; this condition limits muscle growth, recovery, and normal hormonal function.However, FSH levels that are too low can also negatively impact health and reproductive capabilities.
***************************************************************************
Related Product:
| Peptides |
Specification |
Peptides |
Specification |
| MGF |
2mg/vial |
Halodrol |
Customized |
| PEG MGF |
2mg/vial |
Argreline Acetate |
Customized |
| CJC-1295 with DAC |
2mg/vial |
Angiotensin |
Customized |
| CJC-1295 without DAC |
2mg/vial |
Lanreotide |
Customized |
| PT-141 |
10mg/vial |
Arelin Acetate |
powder |
| Melanotan IÂ |
10mg/vial |
Carbetocin Acetate |
Customized |
| Melanotan II |
10mg/vial |
Copper peptide(GHK-Cu) |
Customized |
| GHRP-2 |
5mg or 10mg/vial |
Acetyl tetrapeptide-5 |
Customized |
| GHRP-6 |
5mg or 10mg/vial |
Terlipressin Acetate |
Customized |
| Ipamorelin |
2mg/vial |
SNAP-8 |
Customized |
| Hexarelin |
2mg/vial |
Exenatide acetate |
Customized |
| Sermorelin |
2mg/vial |
Fertirelina |
Customized |
| Oxytocin |
2mg/vial |
Octreotide acetate |
Customized |
| TB500 |
2mg/vial |
Argipressine |
Customized |
| pentadecapeptide BPC 157 |
2mg/vial |
Goserelin acetate |
Customized |
| Â |
2mg/vial |
Decapeptide-12 |
Customized |
| Triptorelin |
2mg/vial |
EYESERYL |
Customized |
| Tesamorelin |
2mg/vial |
Thymosin α1 Acetate |
Customized |
| Gonadorelin |
2mg or 10mg/vial |
Serilesine |
Customized |
| DSIPÂ |
2mg/vial |
Palmitoyl Tetrapeptide-7 |
Customized |
| Selank |
5mg/vial |
 |
Customized |
| AOD-9604 |
2mg/vial |
Palmitoyl Tripeptide-5 |
Customized |
| Adipotide |
2mg/vial |
Palmitoyl Pentapeptide |
Customized |
| ACE 031 |
1mg/vial |
Myristoyl-Pentapeptide-17 |
Customized |
| GDF-8 |
1mg/vial |
Acetyl tetrapeptide-5 |
Customized |
| Thyrotropin TRH |
powder |
Acetyl Glutamyl Heptapeptide-3 |
Customized |
| Epitalon |
10mg/vial |
Palmitoyl Tripeptide-1(Pal-GHK ) |
Customized |
| Follistatin 344 |
1mg/vial |
Nesiritide Acetate |
Customized |
| Follistatin 315Â Â |
1mg/vial |
Eptifibatide |
Customized |
| Deslorelin |
20mg/vial |
Desmopressin acetate |
Customized |
| Nonapeptide-1 |
1mg/vial |
Teriparatide acetate |
Customized |
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.Â
Â
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC ,Â
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
Â
3. How to cooperate with us?
You can contact us for cooperation through the website contact information, or contact with the salesmen in our company. We will connect you about the specific detail via email.Â
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.
Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price.Â
Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept T/T  , Moneygram , Western Union.
Q6:How long does it take to the goods arrived ?
A:It is Depending on your location,
    For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.
Q7  Do  you  have  any  reshipment  policy ? Â
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our productsÂ
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
Â
Q8Â Â How to proceed order?
Let me konw the items,quantity and the destination contury wihch help me to give you a right price
Please let me know the items you are looking for, quantity and the destination country.After you confirm all details of order, pay money 100% in advance and give us Shipping address.We arrange the shipment at first time after receive payment and offer after-sales service after you receive parcel.
USP Standard Follistatin 315 Powder From GMP Factory Professional Supply for Bodybuilder
USP Standard Follistatin 315 Powder From GMP Factory Professional Supply for Bodybuilder
What is FollistatinÂ
Follistatin is fascinating protein that can increase muscle mass beyond natural potential by suppressing myostatin. Scientists first identified follistatin while examining porcine (re: pig) follicular fluid in the ovaries. Follistatin is naturally found in the skeletal muscle of almost all mammals with advanced or developed characteristics, such as humans, rodents, and cows. Follistatin is high in the non-essential amino acid cystine but unlike most proteins discussed in the fitness world, follistatin has carbohydrates attached to it.Â
Follistatin, specifically Follistatin 344 (FS344), quickly gained popularity in the bodybuilding community as a potential supplement to rapidly increase lean tissue mass. Another protein, follistatin-related gene (FLRG) acts on similar pathways as FS344 regarding its muscle building properties. Increased lean tissue mass could give a bodybuilder an advantage in a competitive setting and be the differentiating factor between first and second place.
Follistatin (FS) was initially identified as a follicle-stimulating hormone inhibiting substance found in ovarian follicular fluid. FS is a high-affinity activin-binding protein that can act as an activin antagonist. Two alternatively spliced follistatin mRNAs exist, encoding mature FS with 288 amino acid (aa) residues (FS-288) and 315 aa residues (FS-315). Natural FS purified from porcine ovaries is primarily a carboxy-terminal truncated form of FS-315 composed of 300 aa residues.
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. Follistatin binds directly to activin and functions as an activin antagonist. specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh).
***************************************************************************
Specification: 1mg/vial
Purity: 98%min
Appearance: White powder
Specific Optical Rotation (c=0.5,10% HAc) :-50.0~-60.0°
Water Content(Karl Fischer): ≤5.0%
Acetate Content(by HPLC): ≤15.0%
Amino Acid Composition: ±10% of theoretical
Purity (by HPLC) :≥98.0%
Single Impurity(by HPLC): ≤1.0%
Peptide Content(by %N): ≥80%
Assay(By Anhydrous, Acetic Acid-free ): 95.0~105.0%
Bacterial Endotoxins : ≤5EU/mg
Storage/Stability: Stored at -20 °C if preferred. Storage in frost-free freezers is not recommended.
***************************************************************************
Follistatin 315 (FST-315):
Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle?stimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an N?terminal atypical TGF binding domain, three Follistatin domains that contain EGF?like and kazal?like motifs, and a highly acidic C?terminal tail. Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-Beta ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin 315 is a 34.7 kDa protein containing amino acids 30-344 of the FST-344 protein.
***************************************************************************
Application of Follistatin
Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle stimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an Nterminal atypical TGF binding domain, three Follistatin domains that contain EGFlike and kazallike motifs, and a highly acidic Cterminal tail. Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-Beta ligands including BMP-2, -4, -6, -7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 37.8 kDa protein containing 344 amino acids .
Follistatin and Muscle Growth:
Follistatin works by binding to and inhibiting transforming grow factor- (TGF-) peptides such as myostatin which is responsible for regulating and limiting muscle growth. Â It's also worth pointing out that myostatin may have a regulatory role in skeletal muscle fibrosis; too much myostatin can impair tissue function and cause chronic disease in vital organs, tissues, and bone marrow. In additional to suppressing the degenerative properties of myostatin, follistatin also suppresses the pituitary gland synthesis and secretion of follicle-stimulating hormone (FSH). [1] High FSH levels in men may indicate that testicles are not functioning correctly; this condition limits muscle growth, recovery, and normal hormonal function.However, FSH levels that are too low can also negatively impact health and reproductive capabilities.
***************************************************************************
Related Product:
| Peptides |
Specification |
Peptides |
Specification |
| MGF |
2mg/vial |
Halodrol |
Customized |
| PEG MGF |
2mg/vial |
Argreline Acetate |
Customized |
| CJC-1295 with DAC |
2mg/vial |
Angiotensin |
Customized |
| CJC-1295 without DAC |
2mg/vial |
Lanreotide |
Customized |
| PT-141 |
10mg/vial |
Arelin Acetate |
powder |
| Melanotan IÂ |
10mg/vial |
Carbetocin Acetate |
Customized |
| Melanotan II |
10mg/vial |
Copper peptide(GHK-Cu) |
Customized |
| GHRP-2 |
5mg or 10mg/vial |
Acetyl tetrapeptide-5 |
Customized |
| GHRP-6 |
5mg or 10mg/vial |
Terlipressin Acetate |
Customized |
| Ipamorelin |
2mg/vial |
SNAP-8 |
Customized |
| Hexarelin |
2mg/vial |
Exenatide acetate |
Customized |
| Sermorelin |
2mg/vial |
Fertirelina |
Customized |
| Oxytocin |
2mg/vial |
Octreotide acetate |
Customized |
| TB500 |
2mg/vial |
Argipressine |
Customized |
| pentadecapeptide BPC 157 |
2mg/vial |
Goserelin acetate |
Customized |
| Â |
2mg/vial |
Decapeptide-12 |
Customized |
| Triptorelin |
2mg/vial |
EYESERYL |
Customized |
| Tesamorelin |
2mg/vial |
Thymosin α1 Acetate |
Customized |
| Gonadorelin |
2mg or 10mg/vial |
Serilesine |
Customized |
| DSIPÂ |
2mg/vial |
Palmitoyl Tetrapeptide-7 |
Customized |
| Selank |
5mg/vial |
 |
Customized |
| AOD-9604 |
2mg/vial |
Palmitoyl Tripeptide-5 |
Customized |
| Adipotide |
2mg/vial |
Palmitoyl Pentapeptide |
Customized |
| ACE 031 |
1mg/vial |
Myristoyl-Pentapeptide-17 |
Customized |
| GDF-8 |
1mg/vial |
Acetyl tetrapeptide-5 |
Customized |
| Thyrotropin TRH |
powder |
Acetyl Glutamyl Heptapeptide-3 |
Customized |
| Epitalon |
10mg/vial |
Palmitoyl Tripeptide-1(Pal-GHK ) |
Customized |
| Follistatin 344 |
1mg/vial |
Nesiritide Acetate |
Customized |
| Follistatin 315Â Â |
1mg/vial |
Eptifibatide |
Customized |
| Deslorelin |
20mg/vial |
Desmopressin acetate |
Customized |
| Nonapeptide-1 |
1mg/vial |
Teriparatide acetate |
Customized |
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.Â
Â
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC ,Â
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
Â
3. How to cooperate with us?
You can contact us for cooperation through the website contact information, or contact with the salesmen in our company. We will connect you about the specific detail via email.Â
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.
Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price.Â
Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept T/T  , Moneygram , Western Union.
Q6:How long does it take to the goods arrived ?
A:It is Depending on your location,
    For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.
Q7  Do  you  have  any  reshipment  policy ? Â
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our productsÂ
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
Â
Q8Â Â How to proceed order?
Let me konw the items,quantity and the destination contury wihch help me to give you a right price
Please let me know the items you are looking for, quantity and the destination country.After you confirm all details of order, pay money 100% in advance and give us Shipping address.We arrange the shipment at first time after receive payment and offer after-sales service after you receive parcel.
USP Standard Follistatin 315 Powder From GMP Factory Professional Supply for Bodybuilder