99% purity raw powder Nintedanib effects on IPF

Model NO.: CAS: 656247-17-5
Product Name: Nintedanib
MOQ.: 1g
Payment: Western Union, Money Gram and Bank Transfer
Shipping Methods: EMS, FedEx, DHL etc
Delivery Time: One workday after payment received
Package: Foil bag or Secret Packing
Appearance: Yellow powder
Categories: Anti idiopathic pulmonary fibrosis
Market: Worldwide
Trademark: ZZYC
Transport Package: foil bag or as Your Demands
Specification: 100g/foil bag
Origin: Hunan China
Model NO.: CAS: 656247-17-5
Product Name: Nintedanib
MOQ.: 1g
Payment: Western Union, Money Gram and Bank Transfer
Shipping Methods: EMS, FedEx, DHL etc
Delivery Time: One workday after payment received
Package: Foil bag or Secret Packing
Appearance: Yellow powder
Categories: Anti idiopathic pulmonary fibrosis
Market: Worldwide
Trademark: ZZYC
Transport Package: foil bag or as Your Demands
Specification: 100g/foil bag
Origin: Hunan China
99% purity raw powder Nintedanib effects on IPF

Trade name: VARGATEF; OFEV
Alias: BIBF 1120;
CAS number: 656247-17-5
Molecular Formula: C31H33N5O4
Molecular weight: 539.62500
PSA: 94.22000
LogP: 3.70270
Physicochemical properties
Density: 1.284g/cm3
Boiling point: 742.199oC at 760 mmHg
Flash point: 402.667oC

Nintedanib is a small molecule tyrosine kinase inhibitor with anti-fibrotic and anti-inflammatory activity. Nintedanib inhibits multiple receptor tyrosine kinases (RTKs): platelet-derived growth factor receptor alpha and beta (PDGFR alpha, beta), fibroblast growth factor receptor 1-3 (FGFR1-3), and blood vessels Endothelial growth factor receptor 1-3 (VEGFR1-3) and Fms-like tyrosine kinase-3 (FLT3), where FGFR, PDGFR, and VEGFR are involved in the pathogenesis of IPF, and Nyinnib can compete for binding to these cells. The adenosine triphosphate (ATP) binding site on the inner receptor kinase domain blocks intracellular signaling and inhibits proliferation, migration, and transformation of fibroblasts. In addition, nidanib also inhibits the following non-receptor tyrosine kinases (nRTK): Lck, Lyn, and Src kinases. It is not clear that it inhibits the effect of FLT3 and nRTK on the efficacy of IPF.

Toxicological research
Genotoxicity
Nintedanib Ames test, in vitro mouse lymphoma cell test, in vivo rat micronucleus test results were negative.
Reproductive toxicity
Oral administration of Nintedanib 100 mg/kg/day in rats (rat exposure in vivo to approximately 3 times the AUC of adult maximum recommended dose MRHD) can cause female reproductive dysfunction, showing increased numbers of lost fetuses after embryo implantation and embryo implantation , Decrease in pregnancy index; no adverse effects on the male reproductive system and fertility. Repeated oral administration of Nintedanib to rats and mice revealed changes in the number and size of corpus luteum in the female ovary. Embryo reabsorption was seen only at a dose of 20 mg/kg/day (exposure equivalent to 1x the AUC at the MRHD dose). The number of females increased.
In an embryonic-fetal developmental toxicity test, pregnant rats and rabbits were orally administered with Nintedanib 2.5 mg/kg/day and 15 mg/kg/day, respectively (exposures were In a two-year carcinogenicity test, mice and rats were orally administered with Nintedanib at 10 mg/kg/day and 30 mg/kg/day, respectively (exposures were defined as auc at the dose of mrhd and the equivalent of auc at the mrhd dose. 4 times) no carcinogenicity.

 



 

Product name

Nintedanib (BIBF 1120)

CAS No.

656247-17-5

Outer Packing

100G/ foil bag

Production date

2018.06.04

Shelf life

2020.06.03

Standard adopted

Enterprise Standard

Items of analysis

Specification

Results

Appearance

Yellow powder

Complies

Identification

HPLC

Complies

Assay (HPLC)
>99.0%  99.8%

Related substance
<1.0%  0.2%

Single impurity

<0.2% 

0.06%

Loss on drying

<1.0%

0.20%

Ignition residue

<0.2%

0.06%

Conclusion

Qualified
 


Other products:

 

Anti-cancer & Antineoplastic Products

CAS No.

Ceritinib Intermediate
1802250-63-0

Gefitinib/ ZD1839/ Iressa
184475-35-2

Floxuridine
50-91-1

Pazopanib
444731-52-6

Pazopanib HCl
635702-64-6

Gemcitabine
95058-81-4

Gemcitabine Hydrochloride
122111-03-9

Cabozantinib/ Cabometyx/ XL184/ BMS907351
849217-68-1

Palbociclib
571190-30-2

Xalkori/ Crizotinib
877399-52-5

Lapatinib/ Tyverb
231277-92-2

Bismaleate Afatinib
850140-73-7

Regorafenib/ BAY 73-4506/ Stivarga
755037-03-7

Vemurafenib/ Zelboraf
918504-65-1

Vandetanib/ Zactima
443913-73-3

Aminoglutethimide/ Cytadren
125-84-8

Methotrexate/ Trexall/ Rheumatrex
59-05-2

Lomustine 98%
13010-47-4

Lomustine 99%
13010-47-4

Selumetinib
606143-52-6

Olaparib/ AZD-2281/ Lynparza
763113-22-0

Mitoxantrone HCl
70476-82-3

Dabrafenib/ Tafinlar
1195765-45-7

Anamorelin
249921-19-5

Osimertinib Mesylate/ AZD9291
1421373-66-1

AP26113/ Alunbrig
1197958-12-5

Sorafenib Tosylate
475207-59-1


Packaging & Delivery:
 
Sufficient stock. To delivery promptly at the very day when receiving the payment.
Sophisticated and professional logistic agent. We take responsibility to provide our customers with fast delivery and secure shipping.
Well-trained and disciplined packing team. Fast and discreet shipment could be arranged to guarante Customs pass.
Packing pictures and tracking code are provided within 12 hours after receiving the payment. Updated tracking information will be provided every other day.
 


Competitive Advantages:
 
Our company is a renowned pharmaceutical manufacturer. All powders are factory directly supplying.
Our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
Our products are of high quality and the most favorable quotation. Free samples are available.
Well discreet packing. Fast and secure delivery by DHL, TNT, FedEx, HKEMS, UPS, etc.
Flexible and Untraceable payment terms.
Exclusive customer service and 24/7 online timely and helpful after-sale service.
 
 

Keywords:
 
Liquid Ste-roids
Legal Injectable Ste-roids
Muscle Building Anabolic Ste-roids
 
 
Tag : ana-bolic ste-roid powder, ana-bolic gear for bodybuilding

  99% purity raw powder Nintedanib effects on IPF

Trade name: VARGATEF; OFEV
Alias: BIBF 1120;
CAS number: 656247-17-5
Molecular Formula: C31H33N5O4
Molecular weight: 539.62500
PSA: 94.22000
LogP: 3.70270
Physicochemical properties
Density: 1.284g/cm3
Boiling point: 742.199oC at 760 mmHg
Flash point: 402.667oC

Nintedanib is a small molecule tyrosine kinase inhibitor with anti-fibrotic and anti-inflammatory activity. Nintedanib inhibits multiple receptor tyrosine kinases (RTKs): platelet-derived growth factor receptor alpha and beta (PDGFR alpha, beta), fibroblast growth factor receptor 1-3 (FGFR1-3), and blood vessels Endothelial growth factor receptor 1-3 (VEGFR1-3) and Fms-like tyrosine kinase-3 (FLT3), where FGFR, PDGFR, and VEGFR are involved in the pathogenesis of IPF, and Nyinnib can compete for binding to these cells. The adenosine triphosphate (ATP) binding site on the inner receptor kinase domain blocks intracellular signaling and inhibits proliferation, migration, and transformation of fibroblasts. In addition, nidanib also inhibits the following non-receptor tyrosine kinases (nRTK): Lck, Lyn, and Src kinases. It is not clear that it inhibits the effect of FLT3 and nRTK on the efficacy of IPF.

Toxicological research
Genotoxicity
Nintedanib Ames test, in vitro mouse lymphoma cell test, in vivo rat micronucleus test results were negative.
Reproductive toxicity
Oral administration of Nintedanib 100 mg/kg/day in rats (rat exposure in vivo to approximately 3 times the AUC of adult maximum recommended dose MRHD) can cause female reproductive dysfunction, showing increased numbers of lost fetuses after embryo implantation and embryo implantation , Decrease in pregnancy index; no adverse effects on the male reproductive system and fertility. Repeated oral administration of Nintedanib to rats and mice revealed changes in the number and size of corpus luteum in the female ovary. Embryo reabsorption was seen only at a dose of 20 mg/kg/day (exposure equivalent to 1x the AUC at the MRHD dose). The number of females increased.
In an embryonic-fetal developmental toxicity test, pregnant rats and rabbits were orally administered with Nintedanib 2.5 mg/kg/day and 15 mg/kg/day, respectively (exposures were In a two-year carcinogenicity test, mice and rats were orally administered with Nintedanib at 10 mg/kg/day and 30 mg/kg/day, respectively (exposures were defined as auc at the dose of mrhd and the equivalent of auc at the mrhd dose. 4 times) no carcinogenicity.

 



 

Product name

Nintedanib (BIBF 1120)

CAS No.

656247-17-5

Outer Packing

100G/ foil bag

Production date

2018.06.04

Shelf life

2020.06.03

Standard adopted

Enterprise Standard

Items of analysis

Specification

Results

Appearance

Yellow powder

Complies

Identification

HPLC

Complies

Assay (HPLC)
>99.0%  99.8%

Related substance
<1.0%  0.2%

Single impurity

<0.2% 

0.06%

Loss on drying

<1.0%

0.20%

Ignition residue

<0.2%

0.06%

Conclusion

Qualified
 


Other products:

 

Anti-cancer & Antineoplastic Products

CAS No.

Ceritinib Intermediate
1802250-63-0

Gefitinib/ ZD1839/ Iressa
184475-35-2

Floxuridine
50-91-1

Pazopanib
444731-52-6

Pazopanib HCl
635702-64-6

Gemcitabine
95058-81-4

Gemcitabine Hydrochloride
122111-03-9

Cabozantinib/ Cabometyx/ XL184/ BMS907351
849217-68-1

Palbociclib
571190-30-2

Xalkori/ Crizotinib
877399-52-5

Lapatinib/ Tyverb
231277-92-2

Bismaleate Afatinib
850140-73-7

Regorafenib/ BAY 73-4506/ Stivarga
755037-03-7

Vemurafenib/ Zelboraf
918504-65-1

Vandetanib/ Zactima
443913-73-3

Aminoglutethimide/ Cytadren
125-84-8

Methotrexate/ Trexall/ Rheumatrex
59-05-2

Lomustine 98%
13010-47-4

Lomustine 99%
13010-47-4

Selumetinib
606143-52-6

Olaparib/ AZD-2281/ Lynparza
763113-22-0

Mitoxantrone HCl
70476-82-3

Dabrafenib/ Tafinlar
1195765-45-7

Anamorelin
249921-19-5

Osimertinib Mesylate/ AZD9291
1421373-66-1

AP26113/ Alunbrig
1197958-12-5

Sorafenib Tosylate
475207-59-1


Packaging & Delivery:
 
Sufficient stock. To delivery promptly at the very day when receiving the payment.
Sophisticated and professional logistic agent. We take responsibility to provide our customers with fast delivery and secure shipping.
Well-trained and disciplined packing team. Fast and discreet shipment could be arranged to guarante Customs pass.
Packing pictures and tracking code are provided within 12 hours after receiving the payment. Updated tracking information will be provided every other day.
 


Competitive Advantages:
 
Our company is a renowned pharmaceutical manufacturer. All powders are factory directly supplying.
Our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
Our products are of high quality and the most favorable quotation. Free samples are available.
Well discreet packing. Fast and secure delivery by DHL, TNT, FedEx, HKEMS, UPS, etc.
Flexible and Untraceable payment terms.
Exclusive customer service and 24/7 online timely and helpful after-sale service.
 
 

Keywords:
 
Liquid Ste-roids
Legal Injectable Ste-roids
Muscle Building Anabolic Ste-roids
 
 
Tag : ana-bolic ste-roid powder, ana-bolic gear for bodybuilding

Â