Pharmaceutical Intermediate Adefovir for Antiviral CAS 106941-25-7

October 31, 2018

  • Model NO.: Adefovir
  • Customized: Non-Customized
  • Suitable for: Adult
  • Purity: >99%
  • Mf: C8h12n5o4p
  • Einecs: 1806241-263-5
  • Appearance: White Powder
  • Usage: Treatment of Chronic Hepatitis B
  • Transport Package: Discreet
  • Origin: China
  • Powder: Yes
  • Certification: ISO 9001, USP, BP
  • State: Solid
  • CAS: 106941-25-7
  • MW: 273.19
  • Melting Point: >260′c
  • Density: 1.88
  • Trademark: HKSC
  • Specification: 1kg/ Foil bag
  • HS Code: 2901210000
Pharmaceutical Intermediate Adefovir For Antiviral CAS 106941-25-7


Quick Detail:

Product Name
 		 Adefovir
Synonym
[2-(6-Amino-9H-purine-9-yl)ethoxymethyl]
phosphonic acid;Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]- (9CI);9-[2-(6-Amino-9H-purin-9-yl)et;Adefovir & Adefovir Dipivoxil; adefovir;2-(6-amino-9h-purin-;Adefovir dipivox (PMEA)
 
CAS NO
106941-25-7
 
MF
C8H12N5O4P
 
MW
273.19
 
EINECS
1806241-263-5
 
Purity
99%
 
Appearance
White Powder
 
Melting Point
>260°C
 
Density
1.88
 
Usage
A nucleotide analog, useful as an oral reverse transcriptase inhibitor (ntRTI) . 
 


Description:

Adefovir is a prescription medicine used to treat (chronic) infections with hepatitis B virus. A prodrug form of adefovir was previously called bis-POM PMEA, with trade names Preveon and Hepsera. It is an orally administered nucleotide analog reverse transcriptase inhibitor (ntRTI). It can be formulated as the pivoxil prodrug adefovir dipivoxil.


Regulating human immune system:

Adefovir dipivoxil regulates the immune system and let the immune system to attack liver cells of the intrusion of HBV , and clear the virus, but this method will develop resistance, at the same time for patients with renal dysfunction or potential renal dysfunction risk, the use of adefovir dipivoxil chronic treatment will lead to renal toxicity. If eating 1 mg every day, in the three months will produce nephrotoxicity, this will lead to severe renal failure. These patients should be closely monitoring renal function and making appropriate dosage adjustments.

Bisphosphonates is quick conversion of adefovir dipivoxil in vivo, adefovir dipivoxil is a kind of single adenosine monophosphate acyclic nucleoside analogues, became to activity of the metabolites of adefovir in cellular kinases by phosphorylation in cellular kinases. A Duff Vee two phosphate through the following two ways to suppress HBV DNA polymerase (reverse transcriptase); one is with the natural substrate of deoxyadenosine triphosphate competition, the second is the integration of viral DNA and induce DNA chain elongation terminated. A Duff Vee two phosphate to HBV DNA polymerase inhibition constant (KI) is 0.1μM, but of human DNA polymeraseα and γ is weak and Ki values were 1.18μM and 0.97 μM.

Anti-viral activity: in the human hepatoma cell line transfected with HBV, the concentration of A Duff Vee inhibited 50% viral DNA replication (IC50) is from 0.2 to 2.5uM. 

Adefovir dipivoxil applies for the treatment of hepatitis B virus replication activity and serum Amino Acid transfer enzyme and persistently elevated liver decompensation adult patients with chronic hepatitis B patients.

Liver injury is often encountered in the course of hepatitis B treatment, hepatitis B therapy is inappropriate, as well as long-term use of drugs on the liver damage, will lead to the occurrence of liver damage.

After long-term taking adefovir dipivoxil tablets, once the withdrawal will aggravate the damage of liver function. Therefore, for stopping taking the patients should be monitored for liver function.

Adefovir dipivoxil is more moderate suitable for long-term use, suitable for patients with lamivudine resistant patients, their chances of producing drug resistance is small, because the amount is less, side effects are small.


Advantage:

1. Rich experience:Our company is a professional production leading factory in China in pharmaceutical area of many years.

2. Discreet package:The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also taken into consideration.

3. Top quality:High quality guaranteed, once any problem is found, the package would be reshipped for you .

4. Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.

5. Fast delivery:we have stock, so we can delivery quickly once payment is received.

6. Quality service:we will give you warm after-sale service,if any question we will reply you within 24 hours.

7. Competitive prices:A discount would be given when you make a large order.


 

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